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Cast- Sonic the Hedgehog 3 (2024) as Shadow (voice)
- John Wick: Chapter 4 (2023) as John Wick
- DC League of Super-Pets (2022) as Batman (voice)
- Matrix: Resurrections (2021) as Neo
- Bill & Ted Face the Music (2020) as Ted 'Theodore' Logan
- Between Two Ferns: The Movie (2019) as Keanu Reeves
- John Wick: Chapter 3 - Parabellum (2019) as John Wick
- Destination Wedding (2018) as Frank
- Replicas (2018) as Will Foster
- Siberia (2018) as Lucas Hill
- John Wick Chapter 2 (2017) as John Wick
- John Wick: Chapter Two (2017) as John Wick
- SPF-18 (2017) as Keanu Reeves
- To the Bone (2017) as Dr. Beckham
- Bad Batch, The (2016) as The Dream
- Neon Demon, The (2016) as Hank
- Daughter of God (2015) as Detective Scott Galban
- Knock Knock (2015) as Evan Webber
- John Wick (2014) as John Wick
- 47 Ronin (2013) as Kai
- Generation Um... (2012) as John
- Side by Side (2012) as Himself (Host)
- Henry's Crime (2010) as Henry
- Private Lives of Pippa Lee, The (2009) as Chris Nadeau
- Day the Earth Stood Still, The (2008) as Klaatu
- Street Kings (2008) as Tom Ludlow
- Lake House, The (2006) as Alex Burnham
- Constantine (2005) as John Constantine
- Scanner Darkly, A (2005) as Fred/Bob Arctor
- Mayor of the Sunset Strip (2004) as Himself
- Thumbsucker (2004) as Dr. Perry Lyman
- Kid's Story (2003) as Neo (voice)
- Matrix Reloaded, The (2003) as Thomas Anderson / Neo
- Matrix Revolutions, The (2003) as Thomas A. Anderson/Neo
- Something's Gotta Give (2003) as Julian
- Hardball (2001) as Conor O'Neill
- Sweet November (2001) as Nelson Moss
- Gift, The (2000) as Donnie Barksdale
- Replacements, The (2000) as Shane Falco
- Watcher, The (2000) as David Allen Griffin
- Matrix, The (1999) as Thomas Anderson / Neo
- Last Time I Committed Suicide, The (1997) as Harry
- Chain Reaction (1996) as Eddie Kasalivich
- Feeling Minnesota (1996) as Jjaks Clayton
- Johnny Mnemonic (1995) as Johnny Mnemonic
- Walk In The Clouds, A (1995) as Paul Sutton
- Speed (1994) as Officer Jack Traven
- Even Cowgirls Get The Blues (1993) as Julian Gitche
- Little Buddha (1993) as Siddhartha
- Much Ado About Nothing (1993) as Don John
- Bram Stoker's Dracula (1992) as Jonathan Harker
- Bill And Ted's Bogus Journey (1991) as Ted "Theodore" Logan / Evil Ted
- My Own Private Idaho (1991) as Scott Favor
- Point Break (1991) as FBI Special Agent Johnny 'John' Utah
- I Love You to Death (1990) as Marlon James
- Bill & Ted's Excellent Adventure (1989) as Ted "Theodore" Logan
- Parenthood (1989) as Tod
- Dangerous Liaisons (1988) as Chevalier Danceny
- Permananet Record (1988) as Chris Townsend
- Prince of Pennsylvania, The (1988) as Rupert Marshetta
- River's Edge (1986) as Matt
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