Natalie Portman is in talks to replace Reese Witherspoon as the lead in Fox Searchlight’s drama "Pale Blue Dot".

Witherspoon departed the role last November due to scheduling conflicts with Season 2 of “Big Little Lies,” though she will continue to produce with Bruna Papandrea.

"Fargo" and "Legion" creator Noah Hawley is directing from a script by Brian C Brown and Elliott Diguiseppi.

"Pale Blue Dot" follows a successful female astronaut who, after coming back home from a mission in space, starts to unravel when confronted by her seemingly perfect American dream life. The film explores the theory that astronauts who spend long periods of time in space begin to lose their sense of reality when they return home.

Source: Press Release